Final Project Meeting in Copenhagen
Time has certainly flown! With the project formally ending in July 2022, project partners gathered in Copenhagen from 28 - 29 June for a final meeting, hosted by Lundbeck. Recent target validation results were the main focus of the meeting. As always, lots has been done but there is still much more to do! Young researchers also had a chance to showcase their results in a poster session with Noemi Asfogo and Aurore Tourville of ICM taking home the best poster prizes. The meeting wrapped up with an inspirational farewell message from our volunteers with Parkinson's from Parkinson's UK, who shared why continued research is so important!
Joint PD-MitoQUANT publication in Cell Physiology
Congratulations to the PD-MitoQUANT research team of Sandeep Chenna (Royal College of Surgeons in Ireland, RCSI), Werner J.H. Koopman (Radboud University Medical Center), Jochen H.M. Prehn (RCSI), and Niamh M.C. Connolly (RCSI) for the May 25th, 2022 publication of their review titled "Mechanisms and mathematical modelling of ROS production by the mitochondrial electron transport chain" in the journal Cell Physiology. DOI: https://doi.org/10.1152/ajpcell.00455.2021
PD-MitoQUANT research presented at Dutch Translational Metabolism Conference
Post-doc Dr Shruti Desai of the Radboud University Nijmegen Medical Centre (RUMC) and Sandeep Chenna of the RCSI will present PD-MitoQUANT research at the 2022 Dutch Translational Metabolism Conference, which will be held in Wageningen on June 13th and 14th (https://www.translationalmetabolism.nl/). Shruti's poster is titled: PD-MitoQUANT: Quantification of Mitochondrial Morphofunction in hiPSC- derived Cortical Neurons. Sandeep's is titled: Systems modelling of mitochondrial bioenergetics and genome scale metabolic modelling to explore molecular defects contributing to pathogenesis in Parkinson’s. The aim of the Dutch Translational Metabolism Conference is to bridge the gap between fundamental research, application in humans and validation at the population level. By assembling all junior and senior metabolic experts, this meeting aims to create more insight into the prevention and/or treatment of metabolic diseases.
PD-MitoQUANT team publication in Cells journal
Congratulations to the PD-MitoQUANT team of Aurore Tourville, David Akbar, Olga Corti, Jochen H. M. Prehn, Ronald Melki, Stéphane Hunot and Patrick P. Michel from ICM, CNRS and RCSI for the publication of their open-access study titled: Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons in Cells on May 13th, 2022. Citation: Tourville, A.; Akbar, D.; Corti, O.; Prehn, J.H.M.; Melki, R.; Hunot, S.; Michel, P.P. Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons. Cells 2022, 11, 1640. https://doi.org/10.3390/cells11101640 Download the paper here.
Neuronet releases Decision Tool for engagement with Regulatory and Health Technology Assessment bodies
Neuronet (Efficiently Networking European Neurodegeneration Research, https://www.imi-neuronet.org/) just launched a new version of their Decision Tool to support engagement with Regulatory and Health Technology Assessment (HTA) bodies. The Decision Tool provides a clickable overview of the processes and procedures for HTA and regulatory interactions at different stages of the development pipeline to help ensure that the outputs being developed by Innovative Medicines Initiative research projects are relevant for regulatory and HTA settings, where applicable. Neuronet, a Coordination and Support Action aiming to support and better integrate projects of the IMI neurodegeneration research portfolio aims to develop tools and services to support IMI neurodegeneration projects in areas where unmet needs have been identified, which include the need for further support for interactions with HTA and regulatory agencies. The Decision Tool can be accessed through the Neuronet Knowledge Base, here: https://kb.imi-neuronet.org/