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The PD-MitoQUANT Project

Today, more than one million people live with Parkinson’s in Europe and this number is forecast to double by 2030. New, more effective treatments are urgently needed – but researchers and companies developing new drugs need to know more about how mitochondrial dysfunction is involved in disease progression and better models are needed for drug discovery and development.

PD-MitoQUANT is an Innovative Medicines Initiative (IMI) project that brings together academic experts, SMEs, pharmaceutical companies from the European Federation of Pharmaceutical Industries and Associations (EFPIA) and patient advocacy organisation Parkinson’s UK to:

  • improve our understanding of mitochondrial dysfunction in Parkinson’s,

  • identify and validate molecular drivers and mechanisms in Parkinson’s, and

  • discover innovative therapeutic targets that can be further progressed by the EFPIA partners in the future.

Latest News

Publication news from DZNE

September 9th, 2022|

Our PI Prof. Donato A. DiMonte of the German Center for Neurodegenerative Diseases (DZNE) and co-authors Michael Helwig, Ayse Ulusoy, Angela Rollar, Sinead A. O’Sullivan, Shirley S. L. Lee, Helia Aboutalebi, Rita Pinto-Costa, Benjamin Jevans, and Michael Klinkenberg announce the publication of "Neuronal hyperactivity–induced oxidant stress promotes in vivo alpha-synuclein [...]

Check out our final newsletter!

August 31st, 2022|

It's hard to believe we reached the end of the project in July 2022. Our final newsletter is now out, with an update on our most recent publications and dissemination activities. You can also read about our last consortium meeting in Copenhagen, including the parting thoughts of our public [...]

Review article from DZNE published in The Lancet

August 25th, 2022|

"AIFM1 beyond cell death: An overview of this OXPHOSinducing factor in mitochondrial diseases," an open-access review article prepared by Lena Wischhof, Enzo Scifo, Dan Ehninger and our PD-MitoQUANT PI Daniele Bano was published in eBioMedicine, part of The Lancet Discovery Science on August 18th, 2022. The research team is based at [...]

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